March 22nd, 2015
CAPER – Web site updated
Register for Pancreasfest and Abstract Forms – CAPERpancreas.org / CAPERpancreas.org – PF15 link
PancreasFest 2015 – July 23-24, 2015
- Academic Pancreas Centers of Excellence
- Novel Strategies for the Treatment of Pancreatic Cancer – Peter J. O’Dwyer, MD
- INSPPIRE – working group
- CAPER – Annual Meeting
- Lipases and pancreatitis (hot topics)
- Acute pancreatitis, chronic pancreatitis, pancreatic cancer, fibrosis, pain, diabetes, and clinical trials.
- Collaborative meetings and Ad Hoc Working Groups … and much more!
July 23-24, 2015
NIDDK/NCI Symposium – linked to PancreasFest 2015
Advances in Biomedical Imaging, Bioengineering, and Related Technologies for the Development of Biomarkers of Pancreatic Disease – Website and Registration.
Jul 22, 2015
CTRC mutations linked to SMOKING to enhance risk of chronic pancreatitis.
The common genetic variant, G60G was found to be linked with chronic pancreatitis, but not acute pancreatitis, especially in smokers. The paper, by LaRusch et al. is FREE at Clinical and Translational Gastroenterology, with an Editorial by Scott Tenner MD
CFTR variants linked to a second type of Cystic Fibrosis that does not affect the lungs.
A paper published in PLoS Genetics by LaRusch and colleagues from the North American Pancreatitis Study II (NAPS2) provides compelling evidence of a group of pathogenic mutations in the CFTR gene that increase the risk for chronic pancreatitis, but not lung disease. CFTR is a molecule that is expressed on epithelial cells that separate the fluids of the body from the outside world. CFTR is a channel that allows negatively charged ions (i.e. anions such as chloride [Cl-] and bicarbonate [HCO3-]) to be pushed from the endothelial cells interior out of the body by a strong electrical charge (the inside of the cell has a negative charge and like charges repulse). The build up of ions outside of the cells cause an increase in osmotic pressure, pulling water and sodium out of the body as well – resulting in fluid secretion. The recent discovery demonstrated that when a molecule inside the epithelial cells called WNK1 is activated, it causes the CFTR molecule to change from the normal chloride channel, to a bicarbonate channel. The new discovery is that 9 mutations were discovered that prevent WNK1 from making the switch, so cells that use CFTR for bicarbonate secretion, including the pancreas, sinuses and male reproductive organs, do not work properly. The pancreas may develop cysts and fibrosis – just like in severe mutations that totally destroy CFTR function and cause classic cystic fibrosis. Download the full paper at PLoS Genetics, or read a more detailed newspaper article from the Pittsburgh Post-Gazette.
July 23 (PM) to July 25, 2014. The focus is on complications of chronic pancreatitis – pancreatogenic diabetes (T3cDM) – pancreatic cancer development and detection. Annual meeting of CAPER and INSPPIRE. Brufsky Award and lecture for clinical excellence in pancreatic cancer research. Workshops and working group meetings for INSPPIRE, North American Pancreatic Study Group (NAPS2-AA, NAPS3), Acute Pancreatitis Working Group, and more…! “In addition to a fantastic program, the cost of having PancreasFest in Pittsburgh is low enough that I can afford to bring my students and post-docs to learn, present their work and meet the leaders in the field” – Miklos Sahin-Toth MD PhD.
The program has been posted (click here for PancreasFest home page)
Recommendations from PancreasFest:
The Guidance statements from are now published in Pancreatology
“Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: Recommendations from PancreasFest 2012“. These specifically address issues surrounding when and how to screen for diabetes, including Type 3c (pancreatogenic diabetes).(Click here for Abstract).
“Total pancreatectomy and islet autotransplantation in chronic pancreatitis: Recommendations from PancreasFest” These recommendations guid physicians in the evaluation and management of patients before, and after TPIAT. Click here for Abstract”
NIDDK-NCI Workshop on Pancreatitis-Diabetes-Pancreatic Cancer: REPORT
June 12-13, 2013. Bethesda MD. By all accounts, the PDPC conference was an overwhelming success. A full report was published in the November 2013 issue of Pancreas. See Program Link.
CME Program on Chronic Pancreatitis
Drs Whitcomb & Forsmark discuss advances in science that translate into better treatment of chonic pancreatitis.
CME credit for physicians
(click on image to open a new page)
PRSS1 – Website.
A new web site has been launched to provide information on the functional consequence of various cationic trypsinogen (PRSS1) mutations. The site is maintained by Dr. Miklos Sahin-Toth and Dr. Balazs Nemeth. Click here to visit.
Personalized approaches to treatment of Pancreatitis.
David Whitcomb MD PhD and Adam Slivka MD PhD discuss the advances in the treatment of pancreatitis using genetics. (View of the Whitcomb lab, University of Pittsburgh)
PEaRL .:. Pancreatitis Education and Research Letter
PEaRL news letter page – See “Patient Information” link above
- previous PEaRLs - PEaRL Page
Pancreas Eduction and Research News (PEARL) – Winter 2012-13.