July 12th, 2016
New issue of PEaRL is published (Summer 2016).
A new issue of the Pancreas Education and Research Letter (PEaRL) has been published and mailed to subscribers. A copy can be down loaded for free (click here [1 MB]). Ideas and comments can be sent to “email@example.com”.
European Pancreas Club (EPC) Approve “Mechanistic Definition of Chronic Pancreatitis”
July 9, 2016. The EPC, in conjunction with leaders of the International Association of Pancreatology (IAP), the Japanese Pancreas Society (JPS) and the American Pancreatic Association (APA) are working to develop an international consensus on the the definition and diagnosis of chronic pancreatitis (CP). This action is necessary because the older definitions were developed before a number of research and conceptual breakthroughs, and because of some conflicting recommendations among local, regional, national and societal recommendations.
The process of developing a consensus definition of CP, which was completed after two years of discussion, and publish in spring 2016 (see Pancreatology. 2016 Mar-Apr;16(2):218-24). On July 9, 2016, in a special session, physicians and scientists attending the EPC meeting debated and then approved the new Mechanistic Definition, as published earlier this year.
Further work on Genetics, and on Pain are discussed at PancreasFest 2016 (see below), with definition and diagnosis of chronic pancreatitis discussed at the IAP meeting in Sendai Japan (August 2016).
PancreasFest 2016 – Preliminary Schedule (Click here)
- Check for updates on www.pancreasfest.org
NIDDK Workshop Linked To PancreasFest 2016!
Chronic Pancreatitis in the 21st Century: Research Challenges and Opportunities. July 27, 2016. University Club, Pittsburgh, PA. (PancreasFest July 27-29, 2016)
Final Program <–Click here
CME Lecture – CFTR Mutations and the Pancreas.
Lecture by David C Whitcomb MD PhD. (Link to UPMC CME)
NIDDK-NCI Fund New Pancreas Research Program
New Consortium to Study Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CSCPDPC)
The National Institutes of Health (NIH) will support research into complex pancreatic diseases through the NIDDK and NCI. The research leaders (principal investigators) and institutions include:
The Clinical Centers:
- UC, ALIYE (University of Iowa)
- PANDOL, STEPHEN J (Cedars Sinai LA)
- CHARI, SURESH T. (Mayo Clinic)
- PARK, WALYTER GWANG-UP (Stanford University)
- FISHER, WILLIAM E (Baylor University)
- FOGEL,EVANS (Indiana University)
- FORSMARK, CHRISTOPHER E (University of Florida)
- VAN DEN EEDEN, STEHPEHEN (Kaiser Foundation)
- CONWELL, DARWIN LEWIS (Ohio State University)
- WHITCOMB, DAVID Clement (University of Pittsburgh)
The Data Coordination and Management center:
- FENG,ZIDING (University of Texas-MD Anderson )
Pancreas Meetings: 2015-2016
- A list of pancreas meetings has been updated for 2015-2016 <Meetings>.
Hereditary Pancreatitis Study:
A research team has developed a new health survey to answer these questions and to inform genetic counselors. They are asking past participants, as well as individuals with a personal or family history of pancreatitis or pancreatic cancer, to help us by completing this survey. It can be completed in 15 minutes. The survey can be accessed at: http://tinyurl.com/PittHP
More instructions and information are available at this link. They are also asking participants if they are willing to provide updates to their personal and family medical information in a 10 minute phone conversation.
For additional information or questions, please contact Celeste Shelton, MS by calling 412-864-2826 or our toll-free number at 1-888 PITT-DNA/1-888-748-8362, or by email at firstname.lastname@example.org.
The study is IRB approved. Participation in this study is completely voluntary.
Genetic Risk of Pancreatic Cancer: Celeste Shelton, with Drs Whitcomb and Brand, provide a technical review of the risk of pancreatic cancer in Gastroentology (2015).
CAPER – Web site updated
News about the Collaboative Alliance for Pancreas Education and Research
Log on for CAPER research webinars / APPRENTICE – CAPERpancreas.org
REPORT: PancreasFest 2015
“This was the best pancreas meeting I have been to in my entire life!“ – multiple attendees.
Pittsburgh, PA, USA – July 22-24, 2015. PancreasFest 2015 (PF15) united more than 200 physicians, scientists and trainees on the campus of the University of Pittsburgh in July 2015. The program highlighted pancreatic cancer research, with a presentation by Professor Peter O’Dwyer, MD from the University of Pennsylvania as the winner of the 2015 Ruth C Brufsky Award for Excellence in Research in Pancreatic Cancer. Other sessions focused on chronic pancreatitis, pancreatic cancer diagnosis, minimizing suffering during pancreatic cancer treatment and the role of pancreatic lipases in pancreatic diseases. There were multiple panel discussions which enabled the the audience and speakers to interact in lively and highly informative debates (Figure).
Professor Julia Mayerle, MD for Ernst-Moritz-Arndt Universität Greifswald, Griefswald, Germany discussing the use of animal models of pancreatitis during a panel discussion as Jeffrey Easler MD, Indiana University, takes notes in the foreground.
The International Study group of Pediatric Pancreatitis In Search of a cuRE (INSPPIRE) sponsored a special meeting at Children’s Hospital of Pittsburgh of UPMC for pediatric pancreatologists. This meeting featured multiple American and international expert speakers discussing special problems of pancreatic disease in children, followed by a targeted case discussion session to address difficult pediatric pancreatitis issues.
The Collaborative Alliance for Pancreatic Education and Research (CAPER) sponsored a young investigators’ meeting to highlight up and coming physician researchers. A poster session included 40 presentations, plus four oral presentations from Enrique de-Madaria MD PhD from Alicante, Spain, Venkata Akshintala MD from UPMC in Pittsburgh, Katherine Morgan MD FACS from the Medical University of South Carolina, and Walter Park MD MS from Stanford University. Georgios Papachristou MD PhD from the University of Pittsburgh presented an update on the APPRENTICE Study – a well-organized international working group of over 30 centers focused on solving problems related to acute pancreatitis. CAPER also honored Professor David C Whitcomb MD PhD with the CAPER Lifetime Achievement and Mentoring Award.
Professor Randall Brand MD (far right) from the University of Pittsburgh and UPMC discusses issues related to evaluation of pancreatic cysts. Other panelists in the picture include Amuer Zureikat MD, William Brugge MD and Anne Marie Lennon MD PhD.
Two special sessions highlighted the effort of ad hoc working groups designed to establish guidelines for Academic Pancreatic Centers of Excellence (APCOE). The goal is to provide guidance for best practice approaches for pancreatic care throughout the United States. The APCOE works is in parallel to the efforts of the National Pancreas Foundation, which is evaluating both academic and non-academic centers to make sure that the patients are directed to high-quality care. Darwin Conwell MD MPH, chief of gastroenterology and hepatology at The Ohio State University, noted that APCOEs have the added responsibility of conducting research to continually improve care, evaluating new and existing tests and their optimal use, and educating the next generation of physician scientists.
CME Program on Chronic Pancreatitis
Drs Whitcomb & Forsmark discuss advances in science that translate into better treatment of chonic pancreatitis.
CME credit for physicians
(click on image to open a new page)
PRSS1 – Website.
A new web site has been launched to provide information on the functional consequence of various cationic trypsinogen (PRSS1) mutations. The site is maintained by Dr. Miklos Sahin-Toth and Dr. Balazs Nemeth. Click here to visit.
Personalized approaches to treatment of Pancreatitis.
David Whitcomb MD PhD and Adam Slivka MD PhD discuss the advances in the treatment of pancreatitis using genetics. (View of the Whitcomb lab, University of Pittsburgh)
PEaRL .:. Pancreatitis Education and Research Letter
PEaRL news letter page – See “Patient Information” link above
– previous PEaRLs – PEaRL Page
Pancreas Eduction and Research News (PEARL)